ODCs

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1 OMIM reference -
5 associated genes
7 signs/symptoms

PROTEIN INTERACTIONS: 1
COMMON SIGNS: 1

1 OMIM reference -
1 associated gene
7 signs/symptoms

Ondine syndrome

Hereditary cerebral hemorrhage with amyloidosis, Italian type


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	BDNF	(0.56)	APP

Citations in the biomedical literature:

Ondine syndrome		Hereditary cerebral hemorrhage with amyloidosis, Italian type
	Synonym(s): - CCHS - Central congenital hypoventilation syndrome - Congenital central alveolar hypoventilation syndrome - Ondine curse		Synonym(s): - HCHWA, Italian type

	Classification (Orphanet): - Rare genetic disease - Rare neurologic disease		Classification (Orphanet): - Rare genetic disease - Rare neurologic disease - Rare systemic or rheumatologic disease

	Classification (ICD10): - Diseases of the nervous system -		Classification (ICD10): (no data available)

	Epidemiological data: Class of prevalence: unknown Average age onset: neonatal/infancy Average age of death: normal Type of inheritance: autosomal dominant		Epidemiological data: (no data available)

	External references: 1 OMIM reference - No MeSH references		External references: 1 OMIM reference - No MeSH references


COMMON SIGNS	- Seizures / epilepsy / absences / spasms / status epilepticus

Ondine syndrome		Hereditary cerebral hemorrhage with amyloidosis, Italian type
	Very frequent - Dolichocolon / megacolon / megadolichocolon / Hirschsprung's disease - Respiratory distress / dyspnea / respiratory failure / lung volume reduction Frequent - Stillbirth / neonatal death Occasional - Central nervous system / peripheral nerves neoplasm / tumor / carcinoma / cancer - Hypotonia - Intellectual deficit / mental / psychomotor retardation / learning disability		Very frequent - Autosomal dominant inheritance - Facial pain / cephalalgia / migraine - Intracranial / cerebral / meningeal hemorrhage - Transient cerebral ischemia / stroke Frequent - Obnubilation / coma / lethargia / desorientation - Psychic / psychomotor regression / dementia / intellectual decline